Electrodiffusion dynamics in the cardiomyocyte dyad at nano-scale resolution using the Poisson-Nernst-Planck (PNP) equations
Fig 2
Illustration of two alternative representation of ion channels embedded in the membrane.
A: Ion channels are represented as subdomains of the membrane which selectively allow for electrodiffusion of certain ion species. For example, a K+ channel only allows for electrodiffusion of K+ ions. B: The flux through ion channels are represented as internal boundary conditions for the ion concentrations associated with the channel. In this representation, electrodiffusion in the channel is formulated as a boundary condition with a specified flux. This flux can be defined by the integration of the 1D Nernst equation for the specific ion specie under consideration.