Electrodiffusion dynamics in the cardiomyocyte dyad at nano-scale resolution using the Poisson-Nernst-Planck (PNP) equations
Fig 1
Illustration of the considered domain.
A: In the cardiomyocyte, small domains called dyads are located in areas where the membrane of the SR is close to T-tubule membrane. B: In the dyad, Ca2 + channels and sodium-calcium exchangers (NCXs) in the cell membrane are directly apposed to ryadodine receptor channels (RyRs) in the membrane of the SR. C: The computational domain consists of an extracellular space, , a cell membrane,
, and an intracellular domain,
. A part of this domain is used to represent the dyad with an associated part of the cell membrane and extracellular space (T-tubule). D: In the computational domain, ion channels and exchangers occupy specific locations in the cell membrane.