BMDD: A probabilistic framework for accurate imputation of zero-inflated microbiome sequencing data

doi:10.1371/journal.pcbi.1013124

BMDD: A probabilistic framework for accurate imputation of zero-inflated microbiome sequencing data

Fig 4

Performance of BMDD in differential abundance analysis of microbiome data.

: Simulation results for differential abundance analysis under the gamma model. Empirical false discovery rates and true positive rates were averaged over 500 simulation runs. Error bars represent the 95% confidence intervals and the dashed vertical line indicates the target FDR level of 0.05. : (Bottom) Number of discoveries vs. target FDR level for the real datasets; (Top) Empirical FDR vs. target FDR level for the shuffled real datasets. The dashed gray line represents the diagonal. The results were averaged over 100 simulation runs. : Overlaps of differential taxa with target FDR level of 0.1 for the four real datasets, IBD-1, IBD-2, IBD-3 and IBD-4.

doi: https://doi.org/10.1371/journal.pcbi.1013124.g004