GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model
Fig 7
CSD was induced in somatosensory cortex slices by applying a puff of KCl 130 mM. CSD waves were visualized by near infrared intrinsic optical imaging (IOS) with a CCD camera. Two micropipettes, placed about 1 mm (LFP1) and 1.5mm (LFP2) away from the site of CSD induction, were used to record LFPs. Drugs to modulate GABAergic neurons’ synaptic activity were applied to the bath. The activity of GABAergic neurons, which expressed ChR2, was induced by optogenetic illumination with blue light (470 nm). The figure was created in BioRender. Mantegazza, M. (2025) https://BioRender.com/6zlclb8.