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GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model
Fig 6
Simulation of the effect of the experimental conditions on CSD speed.
(A) Experimental results already displayed in Fig 2, showed here as fold change. (B) Effects of 
on CSD propagation speed. Increasing 
from the value that gives control propagation speed (mimicking ISO) results in a saturation in the speed, which corresponds to the plateau in the plot (green arrow). Decreasing 
(mimicking GBZ) results in an increase of the propagation speed (red arrow). The dashed blue line indicates the values of 
that produce a speed equal to that observed with GBZ in the experiments (3.7 mm/min). Here 
and 
. C. Simulation of the modulatory effect of ChR2 activation with blue light on the propagation speed, resulting in an increase in the activity of the GABAergic population and, consequently, also of GABAergic synaptic transmission, which are modeled by increasing c2 and 
, respectively, and that do not modify propagation speed. The black arrow indicates the value of c2 used in (B). Here 
and 
. D. Effects of c2 (extracellular 
generated from the GABAergic neurons) on the propagation speed. Increasing c2 results in a moderate increase in the propagation speed. Here 
and 
. The black arrow indicates the value of c2 used in (B). (E) Simulation of concomitant blocking of 
receptors with GBZ and activation of ChR2, modeled by decreasing 
and increasing c2, respectively, in which the propagation speed shows a large increase (purple arrow). The dashed blue line indicates the value of the parameters that produce a speed equal to that observed with GBZ in the experiments (3.7 mm/min), the dashed orange line those that produce a speed equal to that observed with GBZ + blue light in the experiments (5 mm/min). The black arrow indicates the value of c2 used in (B). Here 
and 
.
doi: https://doi.org/10.1371/journal.pcbi.1013099.g006