GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model
Fig 4
Illustration of CSD propagation over the propagation axis Q of the neural field model.
The length of Q is 2Lx. CSD initiation occurs at the source point marked in red. Each turquoise dot represents a microcircuit of interconnected excitatory and inhibitory neurons (schematically depicted in the diagram inset in green and blue, respectively). Here cei and cee model the connection weights of excitatory synapses on inhibitory neurons and of excitatory synapses on excitatory neurons (self-coupling), respectively. Similarly, cie and cii model the connection weights of inhibitory synapses on excitatory neurons and of inhibitory synapses on inhibitory neurons, respectively. The effect of excitatory and inhibitory neurons activity on the extracellular potassium concentration is represented by the functions and
, respectively. The influence of the extracellular potassium on excitatory and inhibitory neurons is described by the functions
and
, respectively. Fig 4 was created in BioRender. Mantegazza, M. (2025) https://BioRender.com/hfkou4f.