GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model
Fig 3
Effects of the optogenetic activation of GABAergic neurons on CSD propagation speed in the same slice.
A. Schematic representation of optogenetic illumination effects on GABAergic neurons activity and synaptic transmission. B. CSD propagation speed in VGAT-ChR2-tdtomato slices before and during illumination with blue light. C. Schematic representation of the combined effects induced by optogenetic illumination and gabazine on GABAergic neurons activity and synaptic transmission. Figs 3A and 3C were created in BioRender. Mantegazza, M. (2025) https://BioRender.com/90to28g. D. CSD propagation speed in VGAT-ChR2-tdtomato slices perfused with rACSF + gabazine before and during illumination with blue light. The number of slices (n) is indicated below the x-axis. Paired Student’s t-test: p<0.0001.