Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach
Fig 6
The MNTB-LSO synapses are characterized by high refilling and release probabilities.
A) A quantitative fit of Eq 24 with pr = 0.23 & pd = 0.2 to the transient QC dynamics (orange line). B) Model-predicted QC dynamics as per Eq 24 with pr = 0.93 & pd = 0.53 (gray line), and as predicted by solving (2) for a constant release probability pr = 0.93, zero undocking probability pu,i = 0 and a time-varying refilling probability as shown in the inset (green line). C) Model-predicted steady-state QC Fano factors from (16) for constant low probabilities (pr = 0.23 & pd = 0.2 in orange) or high probabilities (pr = 0.93 & pd = 0.53 in green). Only the latter scenario is consistent with fluctuation statistics from the electrophysiological data (shown in blue). D) Model-predicted steady-state correlations between successive QCs from (20) for constant low (orange) and high probabilities (green), with only the latter fitting the experimentally obtained QC correlations (blue). Error bars on the data are the 95% confidence interval on the steady-state statistics as obtained from bootstrapping QCs from stimulus numbers 10 to 3000.