Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach
Fig 5
Fluctuation statistics of the quantal content (QC) for the auditory MNTB-LSO synapses.
A) Results of a whole-cell patch-clamp recording from a single LSO neuron at a 50-Hz challenge for 1 min (3000 stimuli) as obtained from [69]. Each point represents the QC after a single stimulus pulse. B) Normalized QC values to the first 20 stimuli show the initial depression behavior and the subsequent average synaptic depression level. Values are normalized to the first stimulus QC. C) Steady-state QC distribution as obtained using QCs from stimulus numbers 10 to 3000 together with a fit to a binomial distribution. The steady-state QC Fano factor is obtained as , where
denotes the 95% confidence intervals as obtained by bootstrapping. D) The scatter plot between successive QCs from AP number 10 to 3000 shows a weak negative correlation with a Pearson correlation coefficient
.