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Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach

Fig 4

Normalized synaptic depression and QC fluctuation statistics as a function of release and refilling probabilities.

A) Plots of the steady-state QC Fano factor as given by Eq 16. B) Steady-state correlation between successive QCs as given by Eq 20. C) Normalized synaptic depression assumed to be equal to in Eq 13 as a function of the release and refilling probabilities. From panel B, one can see that if both probabilities p_r and p_d are simultaneously high or simultaneously low, this leads to uncorrelated QCs. However, the two scenarios make contrasting predictions on the Fano factor in panel A. In particular, high probability values lead to a Fano factor close to zero, whereas low probability values result in a Fano factor close to one.

doi: https://doi.org/10.1371/journal.pcbi.1013067.g004