Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach
Fig 3
Alternative parameter regimes with identical mean transient QC yield contrasting QC fluctuation statistics.
Different predictions for the QC Fano factor, each resulting in the same mean QC corresponding to pr = 0.15 and pd = 0.05 in Fig 2 (the bottom-most, yellow line). The top line corresponds to the Fano factor FFi predicted for pr = 0.15 and pd = 0.05 from (7). The middle curve is obtained from (7) with a high release probability (pr = 0.9) and a corresponding time-varying refilling probability pd,i to get the same mean synaptic depression. The bottom curve corresponds to (7) with parameters , and here the same mean synaptic depression occurs due to a reduction in the number of docking sites M. In all cases, the undocking probability is assumed to be zero (pu = 0) and each docking site is occupied at the beginning of the AP train (p1 = 1).