How are estimated cellular turnover rates influenced by the dynamics of a source population?
Fig 5
The danger and safe regions in the space defined by the turnover rates of the POI and the precursor populations, along with annotations (in white) of a few well-known cell populations (N: naive T cells, G: granulocytes/neutrophils, M: memory T cells).
This heatmap was generated using the approximation of the label gain rate at the end of the labelling period as derived in this manuscript (i.e., with
from equation 9b). The deuterium labelling curve of any cell population outside the dark blue region must be analyzed along with that of its precursors to accurately estimate the POI’s rates.