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How are estimated cellular turnover rates influenced by the dynamics of a source population?

Fig 3

The estimated turnover rate of the POI underestimates its true turnover rate and reflects its true division rate when precursors differentiate without division into the POI.

The above plots show the distribution of the estimated gain rate, , as a function of the true rates of the precursor population and the POI when . The solid and dashed lines represent slopes of 1 and 2, respectively. The lines with the slope of 1 and 2 show the line where the value of is equal to and twice that of the parameters on the x-axis, respectively. The colours and shapes show four different groups of quantiles calculated based on the sum squared residual (SSR) of the 1000 best fits. For example, the dark red diamonds show the 0-25% quantile group, which are the top 250 best fits among the 1000 best fits.

doi: https://doi.org/10.1371/journal.pcbi.1013052.g003