Distinguishing multiple roles of T cell and macrophage involvement in determining lymph node fates during Mycobacterium tuberculosis infection
Fig 9
Predicting drivers of FDG avidity within a host with LTBI using sensitivity analysis of simulated FDG avidity.
Left panel contains data from 2000 simulated individual diseased LNs and right panel contains data from 3000 individual simulated activated LNs with no granuloma forming. All simulated LNs are taken from the set of 1000 virtual hosts. Shading indicates correlation between parameter and FDG avidity during time interval t (given a parameter is at least significant for 30 days in t). White boxes indicate that the parameter is not significantly correlated with model outcome at any time points in t. A blue color indicates a positive correlation, and red color indicates a negative correlation. Significance alpha = 0.01 after Bonferroni correction. Complete model state descriptions (MR, MI, E4, etc.) can be found in Table 2, and parameters in Tables A, B, and C in S2 Appendix.