Distinguishing multiple roles of T cell and macrophage involvement in determining lymph node fates during Mycobacterium tuberculosis infection
Fig 6
Time-to-sterilization of LN granulomas is driven by macrophage behavior within LTBI hosts.
Time to sterilization for a simulated LN is defined as the first-time post-LN-infection that a LN contains less than 0.5 total bacteria, or one day beyond the end of the simulation did not sterilize (see Methods). (A) Time to sterilization among 308 diseased LNs from 1000 simulated hosts that were sterilized within the 480-day simulation period. (B) Significant PRCC correlates between functional groups of parameters and output of interest, namely time-to-sterilization (significance with alpha = 0.01 after Bonferroni correction). Our analysis used 388 individual diseased LNs with granulomas from 1000 simulated hosts. Complete model state descriptions (MR, MI, E4, etc.) can be found in Table 2 and parameter values in Tables A, B, and C in S2 Appendix.