Distinguishing multiple roles of T cell and macrophage involvement in determining lymph node fates during Mycobacterium tuberculosis infection
Fig 5
Granuloma bacterial loads are driven by a balance of macrophage infection and activation.
Granulomas are pooled from 1000 LTBI hosts. (A) Proportion of 2000 virtual LN granulomas by fate: no bacteria present (sterilized), stable bacterial growth (stable), and uncontrolled bacterial growth at 481 days post lung infection (N = 2000). (B) Summary of sensitivity analysis detailing significant parameters driving total bacterial load. PRCCs are binned into 50-day bins for ease of analysis (see Methods). Shading indicates average PRCC value during a time interval t (given a parameter is at least significant for 30 days in t). White boxes indicate no significant correlation for longer than 30 days in t. A blue color indicates a positive correlation, and red color indicates a negative correlation. Significance alpha = 0.01 after Bonferroni correction. Complete model state descriptions (MR, MI, E4, etc.) can be found in Table 2 in Methods and parameter value description found in Tables A, B, and C in S2 Appendix.