Stochastic gene expression in proliferating cells: Differing noise intensity in single-cell and population perspectives
Fig 4
Increasing randomness in molecular segregation between daughters enhances protein noise differences between single-cell and population perspectives.
(A) Sample trajectories of protein concentration in an expanding cell colony when expression variability is dominated by partitioning noise ( and
in (20)). (B) Comparison of the steady-state protein concentration noise (
) from single-cell (green circles) and population perspectives (brown squares) calculated from simulations of the agent-based model. The solid line represents the analytically-predicted noise level (20). (C) Sample concentration trajectories for the high intrinsic noise scenario (
and
in (20)). Other parameters are taken as
,
). 2000 colonies where simulated for population perspective, 5000 individuals where simulated for single-cell perspective.