Molecular dynamics study of differential effects of serotonin-2A-receptor (5-HT2AR) modulators
Fig 8
Contour plot depicting 50% most sampled TM6-2 and TM3-7 distances across simulations 1-15.
Colored stars represents the state their corresponding X-ray or Cryo-EM structures. It shows the distinct conformational regions (labeled by the 5-HT2A’s state) modulated by different ligands. A putative “axis of activation” is drawn in red along the TM6-2 and TM3-7 axes.