Molecular dynamics study of differential effects of serotonin-2A-receptor (5-HT2AR) modulators
Fig 7
Boltzmann-inverted density plots for TM6–2 and TM3–7 axes, presented in free-energy units (kcal/mol).
Panel A shows simulations conducted without the G protein construct, while panel B displays simulations with the G protein construct present. Arrows indicate the direction of conformational transitions starting from the experimentally determined structures (denoted by stars).