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Molecular dynamics study of differential effects of serotonin-2A-receptor (5-HT_2AR) modulators

Fig 5

Analysis of important inter-side chain distances as identified by the PCA.

(A-B) 5-HT_2A with (R)-69 and 25CN-NBOH, resp.Normalized histograms are shown for simulations 1-8 without the G protein (top row) and simulations 9-15 with the G protein construct (bottom row). (C) Distance between indole-nitrogen of W336^6x48 and amide-oxygen of N376^7x49. (D) Distance between hydroxyl-oxygens of Y254^5x58 and Y380^7x53.

doi: https://doi.org/10.1371/journal.pcbi.1013000.g005