Molecular dynamics study of differential effects of serotonin-2A-receptor (5-HT2AR) modulators
Fig 1
Important features and ligands in the available experimental structures of the 5-HT2AR.
(A) The serotonin-2A receptor with important side chains highlighted. (B) The intracellular side of 5-HT2AR. In red the conformation in its active form and in blue its inactive one. The two arrows represent the intracellular helix distances between TM2-6 and TM3-7, respectivally. Two important distances to discriminate between states (C) An overview of the ligands used for MD simulations.