Revealing cancer driver genes through integrative transcriptomic and epigenomic analyses with Moonlight
Fig 7
Enrichment analysis of predicted mutation-driven driver genes.
Enrichment analysis of (A) mutation-driven driver genes predicted by Driver Mutation Analysis (DMA) in basal-like breast cancer, (B) mutation-driven driver genes predicted by Driver Mutation Analysis (DMA) in lung adenocarcinoma, and (C) driver genes predicted by both DMA and GMA in lung adenocarcinoma. The “MSigDB Hallmark 2020” database was used for the enrichment analyses. The top 10 most significantly enriched terms (adjusted p-value < 0.05) are included. The gene ratio on the x axis is the ratio between the number of predicted driver genes that intersect with genes annotated in the given hallmark gene set and the total number of genes annotated in the respective hallmark gene set. The point sizes reflect the number of driver genes playing a role in the respective hallmark gene set.