Revealing cancer driver genes through integrative transcriptomic and epigenomic analyses with Moonlight
Fig 5
Exploration of predicted driver genes as drug targets.
(A) Distribution of driver gene-drug interactions stratified by cancer type with the number of drug interactions on the x axis and number of driver genes on the y axis. (B-D) Heatmaps visualizing driver gene-drug interactions in (B) lung adenocarcinoma, (C) basal-like breast cancer, and (D) thyroid carcinoma. Only those driver gene-drug interactions where the interaction type was known are included in the heatmaps. The type of interaction is shown in different colors. The driver genes are divided into OCGs and TSGs.