Revealing cancer driver genes through integrative transcriptomic and epigenomic analyses with Moonlight
Fig 4
Survival analysis of predicted driver genes.
(A) Hazard ratios from multivariate Cox proportional hazards regression of 20 of the predicted OCGs in lung adenocarcinoma and of two of the predicted OCGs in thyroid carcinoma. (B-D) Kaplan-Meier survival plots of three of the predicted OCGs in lung adenocarcinoma which were deemed prognostic from multivariate Cox regression analysis: (B) GNPNAT1, (C) RRM2, and (D) SLC2A1. Patients with expression values above and below the median expression level of the respective gene were divided into a high and low expression group, respectively. The p-values represent the significance of difference in survival between the two groups for each gene.