Revealing cancer driver genes through integrative transcriptomic and epigenomic analyses with Moonlight
Fig 3
Enrichment analyses of predicted driver genes.
Enrichment analysis of predicted driver genes in (A) basal-like breast cancer, (B) lung adenocarcinoma, and (C) thyroid carcinoma using the “MSigDB Hallmark 2020” database. The top 10 most significantly enriched terms (adjusted p-value < 0.05) are included. The gene ratio on the x axis is the ratio between the number of predicted driver genes that intersect with genes annotated in the given hallmark gene set and the total number of genes annotated in the respective hallmark gene set. The point sizes reflect the number of driver genes playing a role in the respective hallmark gene set.