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Statistical signature of subtle behavioral changes in large-scale assays

Fig 2

(A) Noisy, tracked contour of a larva in gray and regularized contour in orange.

The head is indicated by a red point and the tail by a black. (B) 1. Close-up of six points of the larva contour. Vectors between these points represent the contour. The jth point is denoted M_j, its tangent vector , and the curvature at this point . 2. Two larval outlines at time t and t + dt; the vectors show the movement of two selected points during the time-lapse dt. 3. Change of the contour points after the surface energy is minimized. (C) Results of the algorithm applied to two different larvae at four different time steps with the tracked contour in black and the inferred one in orange. The larva’s trajectory is drawn in black, and its center of mass is indicated by a red dot (see also S1 Video).

doi: https://doi.org/10.1371/journal.pcbi.1012990.g002