Evaluating the limitations of Bayesian metabolic control analysis
Fig 6
Elasticity predictions for model variations with strong allosteric regulators.
BMCA-predicted elasticities from ten different perturbation strength datasets for (A) TopA and (B) TopB, each with one or two strong allosteric regulators (Hill coefficient = 3 or 4). Each dot represents the median of the predicted distribution means across the ten enzyme perturbation strengths. The pink dashed line indicates the ground truth elasticity of the first regulator, and the green dashed line indicates that of the second regulator.