Evaluating the limitations of Bayesian metabolic control analysis
Fig 3
Comparison of BMCA predictions from the emll method and the v-based method on TopB.
(A) Elasticities, (B) CCCs, and (C) FCCs predicted by BMCA for TopB using both the emll and v-based methods. No data were omitted, and no allosteric regulation was present. Each dot represents the median of the predicted distribution means across ten different enzyme perturbation strengths. Error bars indicate the range of these predictions. (D) Elasticity predictions from the emll method for TopA with a strong allosteric regulator (ground truth elasticity = –3.61). The method was applied to ten datasets with varying enzyme perturbation strengths; colored dots indicate which dataset each prediction came from. The gray dashed line marks perfect agreement with ground truth values, and the pink dashed line marks the ground truth elasticity of the regulator.