Seizure and redox rescue in a model of glucose transport deficiency
Fig 4
Lactate fluxes describe the role of ANLS in control condition, in GLUT1-DS and during treatment protocol.
In the neuron (left panel) and astrocyte (right panel), LAC fluxes were elevated in all treatment conditions compared to control, suggesting a role for increased LAC availability in treatment success outcomes. Non-negative fluxes in both neuron and astrocyte during treatments results from increased LAC production from dietary supplementation.