Seizure and redox rescue in a model of glucose transport deficiency
Fig 2
Metabolite concentration variability is higher in astrocytes than in neurons, both in control and GLUT1 deficiency.
a) in control simulations (left), and in GLUT1-DS (right), the coefficient of variations (CV) for metabolites for all major subgroups: redox; TCA cycle (TCA), pentose phosphate shunt (PPP), glycolysis (GLCLS), electron transport chain (ETC), and adenosine phosphates (ATDMP). Variations are significantly higher in all groups except the redox molecules (NADH, NADPH, GSH); b) log CV distributions for control (left, green) and GLUT1-DS (right, orange) and comparing neurons (lighter shade) and astrocytes (darker shade), dotted line is the mean of the distribution, solid line is median. Two of each type, neuron and astrocyte; c) side-by-side comparisons show that in addition to higher overall metabolite concentration variability in astrocytes than neurons, there is also a higher variability in the GLUT1-DS condition in both astrocytes and neurons (black bars represent 95% confidence intervals).