Structure-based mechanism of RyR channel operation by calcium and magnesium ions
Fig 7
The residue importance in the activation pathways.
The RI was calculated for all detected activation paths and mapped on the RyR sequences. The graph displays only RI > 0.05. The color-coded marks under the sequence axis indicate the positions of important residues from Tables 3 and 4, see the legend at the bottom: ACT – Ca2+-binding activation site, INH – M2+-binding inhibition site. ATP – ATP-binding site, CFF – caffeine/xanthine binding site, S23 – S23 loop, S45 – S45 linker, GATE – channel gating residues.