Structure-based mechanism of RyR channel operation by calcium and magnesium ions
Fig 4
The RMSD analysis of RyR structures.
Horizontal axis – RMSD100 of the RyR structures relative to the closed RyR1 structure 7k0t. Vertical axis – RMSD100 of the RyR structures relative to the inactivated RyR1 structure 7tdg. The circles of 1 Å radius are centered on the mean RMSDs of the corresponding group of RyR isoforms and states and appraise the significance of differences between groups (when the corresponding circles do not intersect the difference is significant). The solid circle data points and the solid circle lines indicate RyR1 data; the solid triangle data points and the dashed circle lines indicate RyR2 data. Colors indicate RyR states (see inset). C-like and I-like grey bands indicate the similarity of RMSD100 values to either the closed or inactivated reference states.