Structure-based mechanism of RyR channel operation by calcium and magnesium ions
Fig 3
Number of interactions and area between the EF-hand region and S23* loop in RyR structures.
Circles – RyR1 structures; Triangles – RyR2 structures; Black – closed state; Blue – primed state; Cyan – open state; Green – inactivated state; Magenta – high-Mg state. Orange squares – inactivated RyR1 with MH mutations R4736W, R4736Q; Red squares – inactivated RyR1 with MH mutations G4733E, F4732D. RRyR1, RRyR2 – Pearson’s correlation coefficients for RyR1 and RyR2 data groups (solid lines); nRyR1 = 27; nRyR2 = 17; p < 0.005 in both cases). Note: the correlations were calculated without the data for mutated structures (squares). The dashed line extrapolates the correlation line.