Structure-based mechanism of RyR channel operation by calcium and magnesium ions
Fig 2
Distances between key amino acid pairs of the EF-hand and S23* in RyR structures.
Left – Distances D1 between the Cα atoms of E4075 and R4736* or equivalent. Right – Distances D2 between the Cα atoms of K4101 and D4730* or equivalent. Circles – RyR1 states. Triangles - RyR2 states. C – closed state, black symbols. P – primed state, blue symbols. O – open state, cyan symbols. I – inactivated state, green symbols. Mg – high-magnesium state, magenta symbols. Short lines – the median values of groups. Long lines – the theoretical maximum distances allowing H-bond formation.