Simulating dynamic insecticide selection pressures for resistance management in mosquitoes assuming polygenic resistance
Fig 10
Comparison of Sequences, Rotations and Mixtures for Polysmooth.
Left column: Sequences versus Rotations; Centre column: Mixtures vs Rotations; Right column: Mixtures vs Sequences. Colours indicate which strategy had the longer operational lifespan in the direct comparison. Red = rotations longer. Blue = Sequences longer. Purple = Full-Dose Mixtures longer. Draws were excluded from the histogram, but reported in the grey boxes. The number of draws is that obtained from the 5000 parameter sets summarised in the panel. The rows indicate the amount of cross resistance between the two insecticides. Simulations were terminated when no insecticides were available for deployment (because resistance had evolved to them all), or the 500-generation (~50 years) cap was reached. Simulation duration (in years) therefore measures operational lifespan of the IRM strategy. Alternating high and low bars are because simulations with two insecticides are more likely to terminate in even years, thus a difference as a multiple of two years is more likely than as a multiple of 1 year.