Mycobacterium susceptibility to ivermectin by inhibition of eccD3, an ESX-3 secretion system component.
Fig 5
M. tuberculosis ESX-3 secretion system protomer 1.
(a) Protomer 1 interactions with the five drugs having Z-score values less than -1. Molecular interactions between Protomer 1 interface amino acids with (b) ivermectin, (c) moxidectin, and (d) avermectin in 2D diagram. Ligplot was used for 2D map. EccD3-1, refers to extended monomer and EccD3-2, refers to bent monomer.