Mycobacterium susceptibility to ivermectin by inhibition of eccD3, an ESX-3 secretion system component.
Fig 4
M. tuberculosis ESX-3 periplasmic domain EccB3.
(a) EccB3 interactions with the five drugs having Z-scores values less than -1. (b) EccB3 dimer interface interaction with selamectin. (c) Molecular interactions between EccB3 interface residues and selamectin in 2D diagram. Ligplot was used for 2D map.