Comparison of in silico predictions of action potential duration in response to inhibition of IKr and ICaL with new human ex vivo recordings
Fig 1
Experimental measured ex vivo under various drug conditions in human ventricular trabeculae, as a function of
and
inhibition and cubic surface approximating the trabeculae data points in the background.
and
inhibition were computed using the Hill equation (Eq 1), with the CiPA (left) and Pharm (right) datasets. The bottom panels report the inter-trabeculae variability observed experimentally. The marker type indicates the drug used to apply the
and
inhibition.