Mathematical modeling unveils the timeline of CAR-T cell therapy and macrophage-mediated cytokine release syndrome
Fig 8
Blocking of macrophage activation and cytokine release. A Simulation results of interventions reducing mechanisms of macrophage activation one at a time, showing the reduction in IL-6 peak for each patient (gray curves) and mean effect (colored curves). For a simulated 50% reduction (dashed line, fourth panel) the overall reduction in IL-6 peak is indicated for each mechanism. B Simulation results of interventions blocking CD40 starting 0-10 days after CAR-T cell infusion, stopping -5, 0 and 5 days after CAR-T cell peak. The plots show the resulting reduction in IL-6 peak for each patient (gray curves) and the mean effect (colored curves).