Mathematical modeling unveils the timeline of CAR-T cell therapy and macrophage-mediated cytokine release syndrome
Fig 2
Model simulations. Model fits for selected patients that showed response to therapy (P01, G01, M57, and M68) or relapse either of antigen-positive tumor cells (L02, L04) or antigen-negative tumor cells (G02, and M44). See S1–S4 Figs for all 25 patients and Methods for details on parameter estimation. Although patients M57 and M68 were simulated until their PFS day, plots show their dynamics for 60 days for clarity. Tumor cell error bars represent the range of WBCs used in scaling while error bars for IL-6 in patients M44, M57, and M68 encompass the range reported in [32]. The CAR-T cell detection threshold of cells is represented by the gray shaded area.