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Noradrenaline and acetylcholine shape functional connectivity organization of NREM substages: An empirical and simulation study
Fig 3
Optimal parameters and goodness of fit across stages and modalities.
(A) Optimal parameter variation (
and 
), where the euccorrelation metric between empirical and simulated FC matrices is minimized, displayed for all stages in the homogeneous and heterogeneous simulation cases. Arrows represent the direction of change from one state to the next (note that for homogeneous modulation W and N2 are in the same spot). (B) Optimal parameters for the homogeneous and heterogeneous simulation cases, displayed side by side for each stage, for ease of view. Notice the apparent “flipping" of the y axis for the coupling parameter, which arises because we are modeling a decrease in ACh as an increase in G. (C) Violin plots comparing the euccorrelation metric between the simulated and empirical FC matrices, in the optimal, across 50 seeds, for all stages (* for p < 10−3, ** for p < 10−4, *** for p < 10−22, **** for p < 10−50, see Cohen’s D interpretation in Methods).
doi: https://doi.org/10.1371/journal.pcbi.1012852.g003