ChromaFactor: Deconvolution of single-molecule chromatin organization with non-negative matrix factorization
Fig 2
Visualization of NMF outputs and their relationship to single-cell behavior.
a. UMAP visualization of contribution matrix, colored by the template with the predominant contribution in each cell. b. Depiction of cell coordinates from selected individual cells. c. Component contributions for each cell, emphasizing high weight for templates 5, 1, and 0. d. Distance matrices corresponding to each cell. e. Denoised reconstructions of the distance matrices, created by multiplying the template contribution of a cell shown in (c) by the template matrix. f. NMF templates 5, 1, and 0, which had the highest weight contributions for the three individual cells in (c). g. Median contact distance across all cells in the dataset with the highest weight contributions to templates 5, 1, and 0, respectively.