Analysis of systemic effects of dioxin on human health through template-and-anchor modeling
Fig 8
Computational results from the biosynthesis anchor model (adapted from [13]).
Left Panel: The dose-response curve of the effect of dioxin on the biosynthesis rate of hepatic cholesterol is expressed as the percent of remaining activity in comparison with the control. The trendline was matched to fit experimental data (symbols) on mice [60,61]. Right Panel: The model results were formulated as a dose-response relationship characterizing the effect of dioxin on the steady-state amount of hepatic cholesterol.