Analysis of systemic effects of dioxin on human health through template-and-anchor modeling
Fig 3
Anchor model of female steroidogenesis, describing the estradiol synthesis pathway, its regulation, and perturbation by dioxin.
Molecules are color-coded by type, as indicated. Solid lines show reactions and transport steps, with the red solid line signifying the 20,22-desmolase reaction (k_Des), which is affected by dioxin. Dashed lines represent feedback regulation (red) from estradiol and progesterone on the synthesis and release of FSH and LH hormones from the pituitary to plasma, exerting control over the development of the antral follicles and the corpus luteum. Key genes are displayed in grey rectangular boxes.