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Decoding biomolecular condensate dynamics: an energy landscape approach

Fig 7

The self part of the van Hove distribution function of the sticker residues, , are shown with the color scheme indicating the temporal evolution: dark colors represent the earlier distribution (t ~ 10τ), whereas light colors depict the late-time behavior ().

All the curves correspond to distributions taken at the same time intervals. Gaussian fits are shown for the early time (t ~ 10τ, blue dashed line) and late time (, red solid line). (A–C) represent chains with periodic sticker patterns having periods 10, 25, and 100, which remain Gaussian at long times. (D) shows chains with a sticker periodicity of 25 and shuffled stickers, which also remain Gaussian at long time. However, (E) depicts chains with a sticker periodicity of 25 and alternating sticker-spacer arrangements, which deviate from Gaussian behavior. (F) corresponds to R₂₅ (other shows similar behavior), chains with randomly arranged beads, which fail to exhibit Gaussian behavior at long times, indicating the lack of spatial organization in the system.

doi: https://doi.org/10.1371/journal.pcbi.1012826.g007