Decoding biomolecular condensate dynamics: an energy landscape approach
Fig 6
Tangent-tangent correlation in condensates was calculated for the periodically distributed (A–E) and randomly distributed (F) stickers.
(A) For , periodic sticky regions aggregate; however, the chains show uniform exponential decay correlation. (B)
shows anomalous exponential decay in
, indicating a folded structure. (C)
displays diverse position-dependent residue characteristics and long-range order; spacer residues show exponential decay, while spool-like folded domains show non-exponential decay and negative correlation. (D)
also shows anomalous exponential decay, and (E)
has distinct exponential decay lengths. (F) A collapsed exponential decay in the tangent correlation of randomly distributed chains (
,
,
) exhibits worm-like chain behavior with a persistence length of
.