Structural prediction of chimeric immunogen candidates to elicit targeted antibodies against betacoronaviruses
Fig 2
Relative sequence entropy among analyzed coronavirus spike proteins.
Sequence entropy was calculated for a multiple sequence alignment of all coronavirus sequences used and rendered on the 6VSB structure, where green represents lowest sequence entropy and blue represents highest. As expected, the receptor-binding domain and N-terminal domain have the greatest sequence entropy, and loops tend to have higher entropy than adjacent structural elements.