Design of field trials for the evaluation of transmissible vaccines in animal populations
Fig 2
Differences in cumulative infection burden depend on whether the trial is anticipatory or reactionary, and if the contact structure is overdispersed.
Left panel: anticipatory trial with no overdispersion in contact structure. Middle panel: reactionary trial, where vaccination starts once 0.5% of the population has been infected, with no overdispersion in contact structure. Right panel: anticipatory trial with overdispersion in contact stricture (k=1). Observation period is 150 days. Parameters set at: R0,v = 1.1, R0,w = 2, proportion initially recovered = 0, vaccine efficacy = 80%, initial vaccinated proportion, α = 5%.