Internal cohesion gradient as a novel mechanism of collective cell migration
Fig 8
Effect of internal migration on cluster motion.
100 simulation means of cluster migration speed for three cases using Standard Linear Solid (SLS) model. Green: persistent motion of cluster is seen when only outermost cells in cluster wander stochastically. All other parameters from Fig 7C. Red: identical simulation in which all cells wander randomly, demonstrating that wandering of internal cells interferes with cluster migration. Blue: hybrid simulation in which outermost cells wander as in the green case, but all other cells migrate with σ reduced by 75%. Evidently, persistent cluster migration depends on suppression of wandering of interior cells.