Data-driven model discovery and model selection for noisy biological systems
Fig 7
Model discovery of cell state transition dynamics from scRNA-seq data.
A. Diagram of possible cell state transitions during epithelial-mesenchymal transition (EMT). B. EMT data generated with uncertainty estimates for model training from scRNA-seq of cell state transitions over pseudotime. C. Simulations from ODE model inferred by base SINDy. D. Simulations from ODE model inferred from the hybrid model (Eq 9); model equations of the inferred model (right). x1: epithelial cell state; x2 intermediate cell state; x3: mesenchymal cell state. E. Simulations from ODE model inferred from the pure NN model. For C–E, the vertical dashed lines indicate the end of time span on which the inferred models were trained.